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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Toomas Erik Anijärv1, Ruben Smith2,3, Lyduine E Collij4,5,6

  • 1Clinical Memory Research Unit, Lund University, Lund, Sweden.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Tau pathology asymmetry in Alzheimer's disease (AD) is linked to amyloid-beta (Aβ) distribution, not reduced brain connectivity. This suggests hemisphere-specific vulnerability to early Aβ influences tau spread in AD patients.

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Area of Science:

  • Neuroscience
  • Alzheimer's Disease Research
  • Brain Imaging

Background:

  • Alzheimer's disease (AD) is characterized by heterogeneous tau pathology distribution, including hemispheric asymmetry.
  • The underlying mechanisms of tau asymmetry remain unclear, prompting investigation into its relationship with inter-hemispheric connectivity and amyloid-beta (Aβ) distribution.

Purpose of the Study:

  • To explore whether tau asymmetry in AD is associated with reduced inter-hemispheric connectivity or reflects asymmetry in Aβ distribution.
  • To determine if Aβ distribution influences tau spread and hemisphere-specific vulnerability in AD.

Main Methods:

  • Utilized tau-PET scans from 837 Aβ-positive participants in the Swedish BioFINDER-2 cohort.
  • Compared inter-hemispheric structural and functional connectivity across tau asymmetry groups (left asymmetric, symmetric, right asymmetric).
  • Investigated the association between Aβ and tau laterality patterns cross-sectionally and longitudinally, validated in independent cohorts.

Main Results:

  • No significant differences in inter-hemispheric connectivity were found between tau asymmetry groups.
  • A strong association was observed between tau and Aβ laterality patterns, replicated across independent cohorts.
  • Baseline Aβ asymmetry predicted longitudinal tau laterality progression, particularly in individuals without baseline tau pathology.

Conclusions:

  • Tau asymmetry in Alzheimer's disease is not driven by macro-scale inter-hemispheric connectivity differences.
  • Findings suggest that tau asymmetry reflects hemispheric vulnerability influenced by Aβ pathology distribution.