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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Anthonin Reilhac1, Tammie L S Benzinger2, Kristin R Wildsmith1

  • 1Eisai Inc., Nutley, NJ, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Tau PET tracer MK6240 off-target signal (OTS) is influenced by age, gender, and scan time. The pons is a more reliable reference region than the cerebellum for improved diagnostic accuracy in Alzheimer's disease detection.

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Area of Science:

  • Neuroimaging
  • Nuclear Medicine
  • Alzheimer's Disease Research

Background:

  • Tau PET tracer MK6240 can exhibit off-target signal (OTS) in non-brain regions.
  • This off-target signal can impact SUVr values in target and reference regions.
  • Understanding factors influencing OTS is crucial for accurate diagnostic interpretation.

Purpose of the Study:

  • Investigate the impact of demographics and scan time on MK6240 OTS.
  • Assess how different reference regions affect diagnostic separation.
  • Improve the accuracy of MK6240 PET imaging by identifying mitigation strategies for OTS.

Main Methods:

  • Analyzed 764 baseline and 184 follow-up MK6240 PET scans from healthy controls, MCI, and AD participants.
  • Generated SUVr images using cerebellar, centrum semi-ovale, and pons reference regions.
  • Visually rated OTS severity and performed statistical comparisons with demographic and clinical variables.

Main Results:

  • OTS was negatively correlated with age and positively correlated with scan time.
  • Females showed higher OTS than males; no correlation with amyloid status or cortical tau SUVr.
  • The pons demonstrated greater reliability as a reference region compared to the cerebellum.

Conclusions:

  • Demographic factors and scan time significantly influence MK6240 PET OTS.
  • The pons is a more reliable reference region, enhancing diagnostic separation in Alzheimer's disease.
  • Optimizing reference region selection can improve the clinical utility of MK6240 PET.