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Clinical Manifestations.

Rachel N Schade1, Andrew O'Shea2, Katie Rodriguez1

  • 1University of Florida, Gainesville, FL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Older adults worried about subjective cognitive complaints (SCC) show poorer performance on spatial memory tasks, potentially linked to mood and motivation rather than hippocampal changes. This suggests worry may indicate early preclinical Alzheimer's disease (AD).

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Gerontology

Background:

  • Subjective cognitive complaints (SCC) are linked to hippocampal changes and increased risk for preclinical Alzheimer's disease (AD).
  • Individuals with SCC experiencing distress (
  • worried
  • ) may represent a distinct subgroup at higher risk.
  • This study investigated differences between worried and non-worried individuals with SCC.

Purpose of the Study:

  • To compare hippocampal task performance and volumetrics between worried and non-worried individuals with SCC.
  • To determine if mood and/or motivation influence cognitive performance in these groups.
  • To explore potential links between SCC worry and preclinical AD indicators.

Main Methods:

  • 154 adults with SCC were divided into "worried" (N=76) and "non-worried" (N=78) groups.
  • Cognitive assessments included hippocampal-based tasks (ARENA, MST).
  • Mood (BDI-II, AS, STAI) and hippocampal volumetrics were analyzed using ANCOVAs and t-tests.

Main Results:

  • The worried group performed significantly worse on spatial navigation (ARENA) tasks but not on pattern separation (MST).
  • No significant differences in hippocampal volume were found between groups.
  • Worried individuals reported higher levels of depression, anxiety, and apathy, with apathy partially mediating ARENA performance differences.

Conclusions:

  • Worry about SCC in older adults is associated with increased mood and motivation symptoms, impacting cognitive task performance.
  • The spatial navigation task (ARENA) may be sensitive to cognitive changes related to mood, potentially reflecting early AD.
  • The findings suggest that the "worried" SCC group might represent individuals experiencing preclinical AD changes.