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Clinical Manifestations.

Alper Kursat Uysal1,2, Sai Shanmukh Varma Rudraraju1, Sai Santosh Reddy Danda1

  • 1University of Michigan-Dearborn, Dearborn, MI, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
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Summary
This summary is machine-generated.

Older adults with amyloid-positivity (Aβ+) showed longer driving trips and more night driving, suggesting potential early Alzheimer's disease indicators. Amyloid-negative (Aβ-) drivers completed more valid trips, indicating better device operation.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Transportation Safety

Background:

  • Subtle driving changes in older adults may signal early Alzheimer's disease (AD).
  • Brain amyloid positivity is a strong indicator of AD.
  • Naturalistic driving data can reveal early cognitive decline markers.

Purpose of the Study:

  • To distinguish older adults with amyloid-positivity (Aβ+) from amyloid-negative (Aβ-) individuals using driving behavior.
  • To identify significant trip-based driving attributes for future machine learning models.
  • To explore the relationship between naturalistic driving patterns and amyloid status.

Main Methods:

  • Analyzed naturalistic driving data from 30 Aβ+ and 30 Aβ- participants (2021-2024).
  • Recorded driving trips over one month using an internet-facilitated data acquisition system.
  • Examined 22 trip-based attributes, including valid and invalid trips, using statistical t-tests.

Main Results:

  • Aβ- drivers had a higher percentage of valid trips (p=0.026).
  • Aβ+ drivers exhibited longer average trip duration (p=0.037) and distance (p=0.049).
  • Aβ+ participants had a higher percentage of weekday night trips (p=0.048).

Conclusions:

  • Higher valid trip percentage in Aβ- participants may indicate better device operation.
  • Longer trips in Aβ+ individuals could suggest less efficient route planning.
  • Increased night driving in Aβ+ group may signify higher risk and potential cognitive changes.