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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Woo-Jin Cha1, Dahyun Yi2, Evgeny J Chumin3,4

  • 1Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Korea, Republic of (South).

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Preclinical Alzheimer's Disease (AD) shows increased default mode network (DMN) functional connectivity (FC) within the network and decreased FC between networks. These changes may reflect compensatory brain activity in early AD.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Radiology

Background:

  • The default mode network (DMN) is affected by beta-amyloid (Aβ) in early Alzheimer's Disease (AD).
  • Limited data exists on how DMN functional connectivity (FC) changes across AD stages.
  • This study investigates DMN FC alterations in preclinical AD.

Purpose of the Study:

  • To identify characteristic DMN FC changes in preclinical AD.
  • To compare DMN FC in cognitively normal (CN), mild cognitive impairment (MCI), and AD dementia groups.
  • To explore the relationship between Aβ deposition and DMN FC.

Main Methods:

  • 396 participants (CN, MCI, AD dementia) from the KBASE cohort (age 55-88).
  • PiB PET and resting-state functional MRI were used.
  • DMN FC was computed, and participants were classified by Aβ positivity (CN-, CN+, MCI+, AD+).

Main Results:

  • The Aβ+ CN (CN+) group showed significantly higher within-DMN FC compared to other groups.
  • The CN+ group exhibited significantly lower between-DMN FC than other groups.
  • These findings indicate distinct DMN FC patterns in preclinical AD.

Conclusions:

  • Increased within-DMN FC and decreased between-DMN FC are characteristic of preclinical AD.
  • These DMN FC alterations may represent compensatory network activation due to early Aβ deposition.
  • Further research is needed to confirm these findings and their implications for AD progression.