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Clinical Manifestations.

Clive G Ballard1, Ellie Pickering1, Abbie Palmer1

  • 1University of Exeter, Exeter, United Kingdom.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

The PROTECT-UK study demonstrates that digital platforms can effectively collect longitudinal data and conduct remote clinical trials in aging adults. This approach ensures high-quality research, participant engagement, and cost-effectiveness for future studies.

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Area of Science:

  • Gerontology and aging research
  • Digital health and telemedicine
  • Genomic research and personalized medicine

Background:

  • The PROTECT-UK initiative established an online cohort of UK adults to support large-scale, high-quality longitudinal data collection.
  • It aimed to provide a cost-effective, low-risk solution for remote and hybrid clinical trials in aging populations.

Purpose of the Study:

  • To assess the feasibility and effectiveness of a digital platform for longitudinal data collection in aging adults.
  • To facilitate remote and hybrid clinical trials, enhancing recruitment and retention.
  • To enable the collection of genomic and other biological samples for advanced research.

Main Methods:

  • Recruitment of UK adults over 40 via a dedicated website and app.
  • Online completion of annual neuropsychological assessments (FLAME battery), health, lifestyle, and neuropsychiatric symptom data.
  • Remote DNA collection and utilization of the platform for consent-for-contact and pre-screening for clinical trials.
  • Participant engagement strategies including cognitive training and regular communication.

Main Results:

  • Over 54,000 participants enrolled, with 30,000 active in the UK cohort; international instances in Norway and Canada.
  • High year-on-year participant retention (up to 80%) and clinical trial retention (up to 95%) with comparable data completeness to in-person trials.
  • Successful recruitment of over 60,000 participants into online trials, including cognitive training and nutritional supplement studies (e.g., Vitamin D, dietary nitrate).
  • Genomic data contributed to studies on schizophrenia, Alzheimer's risk, and identified cohorts with GBA mutations and APOE4 homozygotes.

Conclusions:

  • Digital platform studies can achieve long-term participant engagement through proactive strategies.
  • The PROTECT study validates the remote execution of efficient, high-quality clinical trials.
  • Remote collection of genomic and biological materials via digital platforms significantly enhances research outputs.