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Drug Development.

Huan Ma1, Yulu Yan1, Zihan Wang1

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Summary
This summary is machine-generated.

DL-3-n-butylphthalide (NBP) shows promise in treating early-onset post-stroke cognitive impairment (PSCI). This study found NBP significantly reduced PSCI risk at 12 weeks, suggesting it as a potential therapeutic agent.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Clinical Medicine

Background:

  • Post-stroke cognitive impairment (PSCI) affects one-third of stroke survivors, leading to significant disability and burden.
  • Early-onset PSCI lacks specific treatments, despite its high prevalence.
  • DL-3-n-butylphthalide (NBP), derived from celery seeds, demonstrates mitochondrial protection and microcirculation improvement.

Purpose of the Study:

  • To investigate the efficacy of DL-3-n-butylphthalide (NBP) in treating early-onset post-stroke cognitive impairment (PSCI).

Main Methods:

  • A 24-week blind clinical trial involved 125 participants aged 45-80 with early-onset PSCI.
  • Participants were randomized to receive NBP or conventional treatment.
  • Cognitive function was assessed using the MoCA scale at baseline and at 6, 12, and 24 weeks.

Main Results:

  • NBP treatment was associated with a significantly lower prevalence of PSCI at 12 weeks (52.6% vs. 75.6%, p=0.029).
  • Multivariate logistic regression indicated NBP treatment reduced PSCI risk (OR=0.26, p=0.020), adjusting for key covariates.
  • While PSCI prevalence decreased in both groups, NBP showed a distinct benefit at the 12-week mark.

Conclusions:

  • Combined therapy with NBP accelerated recovery in early-onset PSCI.
  • NBP demonstrates potential as a novel therapeutic agent for early-onset PSCI.