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Drug Development.

Edna N Bosire1, Lucy Wambui Kamau2, Chinedu T Udeh-Momoh2,3

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Summary
This summary is machine-generated.

Understanding dementia clinical trials in Kenya is crucial for advancing research. Enhancing enrollment requires addressing concerns about side effects, research integrity, and cultural beliefs, while highlighting benefits and offering incentives.

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Area of Science:

  • Neuroscience
  • Clinical Research
  • Public Health

Background:

  • Dementia research relies on clinical trial participation to test new treatments.
  • Understanding dementia clinical trials in resource-constrained settings like Kenya is limited.
  • This study explores perceptions of dementia clinical trials in Nairobi, Kenya.

Purpose of the Study:

  • To explore public understanding of dementia clinical trials.
  • To assess attitudes and perceptions towards dementia clinical trials.
  • To identify strategies for enhancing enrollment in dementia clinical trials.

Main Methods:

  • An ethnographic study utilized 8 focused group discussions (FGDs) with 81 participants in Nairobi.
  • FGDs were age and gender stratified, conducted in English and Kiswahili.
  • Thematic analysis of transcribed data was performed using NVivo software.

Main Results:

  • Younger participants showed better understanding of clinical trials than older ones.
  • Willingness to participate varied by age and gender, influenced by perceptions of contributing to a greater good.
  • Hesitancy stemmed from fear of side effects, research integrity concerns, and cultural/religious beliefs.

Conclusions:

  • Study findings can inform strategies to boost dementia clinical research participation in Kenya.
  • Addressing community concerns and highlighting benefits are key to enhancing enrollment.
  • This research contributes to advancing dementia treatment efforts in similar global contexts.