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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Dhamidhu Eratne1,2, Jeff Smith3, Kruti Patel3

  • 1Neuropsychiatry Centre, The Royal Melbourne Hospital, Parkville, VIC, Australia.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
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Summary
This summary is machine-generated.

A new proximity ligation assay (PLA) offers a cost-effective method for detecting neurofilament light chain (NfL) and other biomarkers. This approach promises to improve the diagnosis of neurodegenerative dementias (ND) and psychiatric disorders in routine clinical settings.

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Area of Science:

  • Biomarker discovery and diagnostics
  • Neuroscience and neurology
  • Clinical pathology

Background:

  • Neurofilament light chain (NfL) and phosphorylated tau (p-tau) are promising blood biomarkers for diagnosing neurodegenerative dementias (ND) and differentiating them from psychiatric disorders (PPD).
  • Current diagnostic technologies are expensive and require specialized infrastructure, limiting their widespread clinical adoption.
  • A platform integrated into routine pathology services is needed to enhance accessibility and implementation across various healthcare settings.

Purpose of the Study:

  • To develop and validate a proximity ligation assay (PLA) for detecting neurofilament light chain (NfL).
  • To assess the feasibility of integrating this assay into routine clinical pathology workflows.
  • To evaluate the potential of PLA for improving the diagnosis of neurodegenerative and psychiatric disorders.

Main Methods:

  • Development of a proximity ligation assay (PLA) for neurofilament light chain (NfL) detection.
  • Utilizing samples from The Markers in Neuropsychiatric Disorders Study (The MiND Study), collected from diverse clinical settings.
  • Ongoing analysis of 300 participants with conditions including Alzheimer's disease, other dementias, delirium, bipolar mania, depression, anorexia, and controls.

Main Results:

  • Preliminary data show a strong correlation between PLA detection of NfL and gold-standard platforms (R = 0.86).
  • The PLA method demonstrates high accuracy in distinguishing neurodegenerative dementias (ND) from primary psychiatric disorders (PPD).
  • Further analyses are in progress to confirm findings across a broad spectrum of neurological and psychiatric conditions.

Conclusions:

  • A cost-effective, high-throughput PLA platform for NfL and other biomarkers can revolutionize diagnostics and research.
  • Seamless integration into routine clinical pathology workflows can significantly improve diagnostic accessibility and accuracy globally.
  • This approach holds the potential for better patient outcomes and healthcare system efficiencies.