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Clinical Manifestations.

Andrea Panzavolta1, Alessandra Dodich2, Giulia Funghi2

  • 1Scuola Universitaria Superiore IUSS, Pavia, Pavia, Italy.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
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Summary
This summary is machine-generated.

This study highlights the need for clearer socio-cognitive assessments in neurocognitive disorders (NCDs). Patient and caregiver feedback emphasizes developing measures for real-life social behaviors to improve clinical research and care.

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Area of Science:

  • Neuroscience
  • Psychology
  • Gerontology

Background:

  • Neurocognitive disorders (NCDs) present with socially inappropriate behaviors and altered social cognition, impacting patient-caregiver quality of life.
  • Current interventions for these socio-cognitive impairments are limited, and outcome measures lack standardization, hindering research comparability.

Purpose of the Study:

  • To identify patient-oriented concepts for socio-cognitive clinical research in NCDs.
  • To gather feedback on neuropsychological and socio-cognitive assessments from patients and caregivers.
  • To inform the development of tailored interventions and outcome measures.

Main Methods:

  • An international online survey was distributed to patient and caregiver associations via the SIGNATURE network.
  • The survey assessed perceived clarity and utility of neuropsychological assessments, relevance of socio-cognitive testing, and priorities for social behavior assessment.
  • Data were collected from 198 respondents across six Italian and Spanish caregiver associations.

Main Results:

  • Respondents found cognitive assessments useful for understanding disease progression and daily life deficits.
  • Over 50% reported difficulties with scoring tables and technical terminology, indicating a need for clearer communication.
  • Socio-cognitive testing was highly relevant, with a strong emphasis on measuring real-life social behaviors like empathy and emotional regulation.

Conclusions:

  • Educational initiatives are needed to improve the clarity of socio-cognitive assessments for clinicians and stakeholders.
  • Developing and validating measures of real-life social behavior changes is crucial for socio-cognitive clinical research in NCDs.
  • Patient and caregiver perspectives are vital for advancing research and improving care in NCDs.