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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Abenaa Mensah-Bonsu1, Cristian O Mojica1, Katelyn Elizabeth Mooney2

  • 1University of California, Los Angeles, Los Angeles, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Childhood adversity is linked to accelerated brain aging in White individuals, but not Black individuals. This suggests different factors influence brain aging across racial groups.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Psychology

Background:

  • Adverse Childhood Experiences (ACEs) are linked to cognitive health issues.
  • Brain Age Gap (BAG) prediction using MRI and machine learning assesses brain health.
  • The impact of ACEs on BAG is underexplored.

Purpose of the Study:

  • To examine the association between childhood adversity and accelerated brain aging (BAG).
  • To investigate this association in non-Hispanic Black and White older adults.

Main Methods:

  • Utilized data from the Rush Memory and Aging Project and Minority Aging Research Study.
  • Categorized childhood adversity using median split for Black and White participants.
  • Employed linear regression analyses to assess the association between childhood adversity and BAG, controlling for education and sex.

Main Results:

  • Higher childhood adversity was significantly associated with higher BAG in White individuals (p=0.046).
  • No significant association was found between childhood adversity and BAG in Black individuals.

Conclusions:

  • Childhood adversity may be linked to accelerated brain aging in White individuals.
  • The absence of this link in Black individuals suggests potential social or biological factors influencing brain aging in this population.