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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Dana M Parker1, Michael A Yassa1, Jenna N Adams1

  • 1University of California, Irvine, Irvine, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Specific white matter (WM) locations show disrupted integrity linked to tau pathology and cognitive impairment in Alzheimer's disease (AD). This spatially specific analysis offers new insights into AD's impact on brain connectivity.

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Area of Science:

  • Neuroimaging
  • Neurodegeneration
  • White Matter Integrity

Background:

  • Tau pathology is implicated in white matter (WM) disruption in Alzheimer's disease (AD).
  • Previous studies identified global WM tract disruption, but lacked spatial specificity.
  • Tractometry enables quantification of WM integrity along specific spatial locations within tracts.

Purpose of the Study:

  • To assess WM integrity along medial temporal lobe (MTL) WM tracts.
  • To determine if tau pathology or cognitive impairment is associated with spatially specific WM integrity patterns in older adults.
  • To investigate the relationship between tau deposition, cognitive status, and WM integrity across the AD continuum.

Main Methods:

  • 159 older adults from ADNI3 underwent tau-PET and diffusion MRI.
  • Fractional anisotropy (FA) was calculated for MTL tracts (ILF, UF) at 100 equidistant nodes using pyAFQ.
  • Mixed effects models analyzed interactions between tau, diagnosis, and node location on WM integrity.

Main Results:

  • Significant interactions between tau, diagnosis, and node location were found across all MTL tracts.
  • Tau and diagnosis impacted WM integrity differentially along the tracts, with no significant main effects.
  • Specific nodes in UF and ILF were significantly associated with tau levels and cognitive impairment, particularly in MTL regions.

Conclusions:

  • Assessing WM integrity at specific spatial locations provides more sensitive information in AD.
  • Vulnerable WM nodes identified spatially overlapped with MTL regions known for tau deposition.
  • These findings offer valuable insights into the effects of tau pathology on WM integrity in AD.