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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Lucas He1, Jo Barnes2, Zerui Li3

  • 1MRC Unit for Lifelong Health and Ageing at UCL, London, United Kingdom.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Midlife cardiac function, especially left atrial measures, is linked to white matter hyperintensities (WMH) 5-7 years later. These findings suggest cardiac health impacts brain aging and cognitive decline risk.

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Area of Science:

  • Cardiology
  • Neurology
  • Gerontology

Background:

  • White matter hyperintensities (WMH) are indicators of cerebrovascular disease and linked to cognitive decline.
  • Longitudinal data on heart-brain interactions and WMH development are limited.
  • This study examined midlife cardiac function's association with later WMH burden.

Purpose of the Study:

  • To investigate the longitudinal relationship between midlife echocardiographic parameters and subsequent WMH burden.
  • To explore cardiac function as a predictor of age-related brain changes.
  • To assess heart-brain interactions in a cohort study.

Main Methods:

  • Analysis of 445 participants from the National Survey for Health and Development (NSHD) Neuroimaging sub-study (Insight46).
  • Midlife echocardiographic measurements (systolic, diastolic, structural) at ages 60-64.
  • Brain MRI at ages 69-71 for automated WMH quantification, with statistical analysis using generalized linear models and Benjamini-Hochberg correction.

Main Results:

  • Left atrial volume indexed for body surface area (LAV/BSA) showed the strongest association with global WMH.
  • Regional analysis revealed pronounced frontal lobe effects for LAV/BSA and E/e' ratio.
  • End systolic volume demonstrated a non-linear association with WMH, indicating complex interactions.

Conclusions:

  • Midlife echocardiographic parameters, particularly left atrial measures, are significantly associated with subsequent WMH burden.
  • Findings support integrating cardiac assessments into risk profiling for age-related brain changes.
  • Further research is needed to determine if cardiac health interventions can mitigate WMH accumulation and cognitive risks.