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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

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Biomarkers.

Elisabeth Thijssen1

  • 1Neurogen Biomarking, Chicago, IL, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Phospho-tau217 (p-tau217) blood tests show promise for Alzheimer's disease (AD) diagnosis. This study validates at-home blood collection for p-tau217, improving accessibility for early AD detection.

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Area of Science:

  • Neurology
  • Biomarker Research
  • Gerontology

Background:

  • Phospho-tau217 (p-tau217) is a highly accurate blood biomarker for Alzheimer's disease (AD) pathology.
  • Elevated p-tau217 levels correlate with AD biomarkers and cognitive decline, indicating its potential for early detection.
  • Validating remote blood sampling methods is crucial for increasing access to AD diagnostics.

Purpose of the Study:

  • To validate the Tasso+™ at-home blood collection device for measuring p-tau217 concentrations.
  • To assess the stability and reliability of p-tau217 measurements from remotely collected samples.
  • To compare p-tau217 levels obtained via at-home sampling with traditional venipuncture methods.

Main Methods:

  • A validation study involving 70 healthy volunteers and 60 amyloid-positive AD patients.
  • Blood samples collected using the Tasso+™ device and standard venipuncture.
  • Sample stability tested at room temperature for up to 48 hours; overnight shipping to mimic real-world conditions.

Main Results:

  • Ongoing recruitment; preliminary findings suggest a positive correlation between Tasso+™ and venipuncture p-tau217 concentrations.
  • Receiver Operating Characteristic analysis will determine the accuracy of differentiating AD patients from controls.
  • Study results will be presented at AAIC2025, evaluating Tasso+™ for scalable, non-invasive Alzheimer's biomarker research.

Conclusions:

  • This study validates a novel, non-invasive at-home blood sampling method for p-tau217.
  • Improved accessibility through at-home sampling can facilitate earlier and more frequent Alzheimer's disease detection.
  • This approach has the potential to enhance clinical practice and research, making early AD diagnosis more feasible for a wider population.