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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
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Clinical Manifestations
Yi Fang1, Allysa Quick2, Sasha Milton1
1University of California, San Francisco, San Francisco, CA, USA.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
Summary
In older adults, prolonged sleep duration and excessive time in bed are linked to increased cognitive impairment risk. Difficulty staying asleep may reduce this risk, suggesting sleep monitoring aids detection in advanced aging.
Area of Science:
- Gerontology
- Sleep Medicine
- Neurology
Background:
- Aging impacts sleep and cognitive function.
- Disrupted sleep is linked to cognitive decline.
- Subjective sleep characteristics' relation to cognitive impairment in the oldest old is understudied.
Purpose of the Study:
- To investigate the association between subjective sleep characteristics and incident cognitive impairment.
- To examine these associations across different age groups, particularly the oldest old (90+ years).
Main Methods:
- Harmonized data from four U.S. cohorts (MAP, MARS, MrOS, SOF) were analyzed.
- Sleep measures included duration, time in bed, quality, daytime sleepiness, and sleep difficulties.
- Poisson regression examined associations with cognitive impairment (MCI/dementia) in age-stratified groups, adjusting for covariates.
Main Results:
- Prolonged sleep duration (>8 hours) was associated with increased cognitive impairment risk in the 90+ group (RR=2.167).
- Excessive time in bed (>8 hours) was linked to higher cognitive impairment risk in the 80-90 group (RR=1.201).
- Difficulty staying asleep (>=3 times/week) was associated with lower risk in the 80-90 group (RR=0.831).
Conclusions:
- Prolonged sleep duration and excessive time in bed predict higher cognitive impairment risk in adults over 80.
- These sleep patterns may serve as potential markers for cognitive impairment in advanced aging.
- Tailored sleep monitoring could assist in early detection of cognitive decline.
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