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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Cardiac myocytes produce these hormones in response to ventricular stretching...
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Comparison of [18F]flortaucipir and [18F]MK6240 for the detection of tau pathology in Alzheimer's disease (HEAD): a multicentre, prospective, cross-sectional, within-participant study.

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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Shaney Flores1, Thomas Hunter Smith1, Jalen Scott1

  • 1Washington University School of Medicine, St. Louis, MO, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Off-target tau PET signal from the skull and meninges was more pronounced with 18F-MK-6240 than 18F-AV-1451. Subject-specific masks can help isolate this extra-cerebral signal for accurate Alzheimer

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Area of Science:

  • Neuroimaging
  • Nuclear Medicine
  • Alzheimer's Disease Research

Background:

  • Tau tangle deposition correlates with Alzheimer's disease (AD) symptoms and cognitive decline.
  • In vivo tau deposition is measurable using positron emission tomography (PET).
  • Extra-cerebral signal (skull, meninges) may bias tau PET quantification, but its impact is unclear.

Purpose of the Study:

  • To investigate off-target signal sources in individuals undergoing tau PET scans.
  • To compare extra-cerebral signal between 18F-AV-1451 and 18F-MK-6240 tau PET tracers.
  • To assess the impact of off-target signals on tau PET quantification in Alzheimer's disease research.

Main Methods:

  • Acquired T1-weighted MRI, Pittsburgh Compound B (PiB) amyloid PET, and tau PET in 42 participants.
  • Quantified tau PET using standardized uptake values (SUV) and SUV ratios (SUVRs) with cerebellar grey reference.
  • Developed subject-specific masks for skull bone and meninges using CT and MNI-152 aligned tau PET images.

Main Results:

  • Extra-cerebral off-target signal was more pronounced and widespread with 18F-MK-6240 compared to 18F-AV-1451.
  • The 18F-MK-6240 signal affected the entire cortical surface and posterior cerebellum.
  • This pronounced signal may impact cerebellar reference region-based tau PET SUVR quantification.

Conclusions:

  • Both tau PET tracers exhibit off-target extra-cerebral signal, but it is more significant in 18F-MK-6240.
  • Subject-specific skull and meningeal masks can help isolate and determine the cause of this signal.
  • Further research is needed to explore demographic, health, and genetic factors contributing to this signal.