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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Miriam J Rodriguez1, Batul Yawer2, Patricia Garcia3

  • 1Indiana University School of Public Health, Bloomington, IN, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Alzheimer's disease (AD) blood biomarkers show associations with cognitive function in Hispanic and White-non-Hispanic older adults. Specific biomarkers like ptau217 and NFL were linked to cognitive and functional changes, particularly in Hispanic individuals.

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Area of Science:

  • Neuroscience
  • Biomarker Research
  • Geriatric Medicine

Background:

  • Examined Alzheimer's disease (AD) blood-based biomarkers in relation to cognitive and functional status.
  • Compared associations in understudied Hispanic (n=214) and White-non-Hispanic (WNH) (n=169) older adults.

Purpose of the Study:

  • To compare the associations of AD blood biomarkers with cognitive and functional performance across ethnic groups.
  • To investigate the predictive value of biomarkers for cognitive decline and functional limitations.

Main Methods:

  • Included cognitively normal, PreMCI, MCI, and dementia subjects (n=383 total).
  • Assessed cognitive function and functional limitations (mCDR).
  • Analyzed blood biomarkers (ptau217, abeta40, abeta42, GFAP, NFL) using regression models, controlling for covariates.

Main Results:

  • In Hispanics, ptau217 linked to lower memory and word fluency; NFL linked to lower word fluency and higher functional limitations.
  • In WNH, Abeta40 and GFAP linked to lower letter fluency; ptau217 and abeta42 linked to higher letter fluency.
  • Biomarker associations showed small to moderate effect sizes.

Conclusions:

  • Blood biomarkers are associated with cognitive function in both Hispanic and WNH older adults.
  • Associations with functional limitations were observed primarily in the Hispanic group.
  • Biomarkers may aid in predicting cognitive status and functional impairment in Hispanic ADRD populations, potentially reducing health disparities.