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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Xueping Chen1

  • 1West China Hospital, Chengdu, Sicuan, China; West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Lecanemab treatment showed significant cognitive improvements in Alzheimer

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Area of Science:

  • Neurology
  • Neurodegenerative Diseases
  • Pharmacology

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the primary cause of dementia worldwide.
  • Lecanemab is an approved disease-modifying therapy for mild AD, necessitating real-world efficacy and safety data.
  • Monitoring treatment efficacy using AD-related serum biomarkers is crucial for personalized patient management.

Purpose of the Study:

  • To evaluate the real-world efficacy and safety of lecanemab in Alzheimer's disease patients.
  • To explore the utility of serum biomarkers in monitoring lecanemab treatment response.
  • To identify potential adverse events associated with lecanemab therapy in a real-world setting.

Main Methods:

  • Fifty-one patients meeting ATN criteria for AD were enrolled.
  • Cognitive function was assessed using ADAS-Cog, CDR-SB, MoCA, MMSE, and FAB.
  • Serum biomarkers (NFL, GFAP, Aβ 1-40, Aβ 1-42, p-tau 181, p-tau 217) were monitored.

Main Results:

  • Significant improvements were observed in ADAS-Cog, CDR-SB, and MoCA scores at 7 months.
  • Serum p-tau 181 levels decreased significantly, correlating with cognitive improvements.
  • Infusion reactions and asymptomatic ARIA were observed, requiring monitoring.

Conclusions:

  • Lecanemab demonstrates potential safety and efficacy in treating mild-to-moderate AD in real-world settings.
  • Dynamic monitoring of serum p-tau 181 may aid in assessing treatment efficacy.
  • Close monitoring for adverse events like ARIA is recommended for patients with severe cognitive impairment.