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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Jiaming Lu1, Qian Chen1, Yajing Zhu2

  • 1Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

New Alzheimer's disease (AD) biomarkers found in cerebrospinal fluid (CSF) show high accuracy in diagnosis and predicting disease progression. These metabolomic discoveries offer hope for earlier AD detection and intervention.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Medical Diagnostics

Background:

  • Metabolomic analysis is expanding the potential for discovering new Alzheimer's disease (AD) biomarkers.
  • Cerebrospinal fluid (CSF) metabolomics offers a promising avenue for identifying diagnostic and prognostic markers for AD.

Purpose of the Study:

  • To identify novel cerebrospinal fluid (CSF) metabolite biomarkers for the diagnosis and prediction of Alzheimer's disease (AD).
  • To evaluate the diagnostic and prognostic performance of identified CSF metabolite panels in independent cohorts.

Main Methods:

  • Analysis of 348 CSF metabolites in 635 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) with varying cognitive statuses (CN, MCI, AD dementia).
  • Inclusion of biologically defined AD+ participants and cognitively normal (CN) participants from the Parkinson's Progression Markers Initiative (PPMI) for validation.
  • Assessment of CSF Aβ42 levels and metabolomic profiling using advanced assays.

Main Results:

  • A combination of N-acetylthreonine and choline demonstrated high diagnostic accuracy for biologically (AUC=0.961) and clinically (AUC=0.833) defined AD.
  • Four-metabolite panels achieved superior diagnostic accuracy (AUC=0.987 and 0.871) and were validated in an external cohort.
  • Identified biomarkers effectively predicted clinical progression to AD dementia and correlated with core AD biomarkers and cognitive decline.

Conclusions:

  • The study identified high-performance CSF metabolite biomarkers for Alzheimer's disease (AD) diagnosis.
  • These biomarkers show potential for predicting disease progression and aiding in early AD detection.