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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Biomarkers.

Nadia Ashrafi1, Sangeetha Vishweswaraiah2, Ali Yilmaz2

  • 1Corewell Health Research Institute, William Beaumont University Hospital, Royal Oak, MI, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

This study integrates metabolomics and methylation analysis to uncover Alzheimer

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Area of Science:

  • Neuroscience
  • Genetics
  • Biochemistry

Background:

  • Alzheimer's Disease (AD) is a progressive neurodegenerative disorder with complex etiology.
  • Current AD research often uses single omics approaches, limiting comprehensive understanding.
  • Pathological changes in AD begin decades before symptom onset.

Purpose of the Study:

  • To investigate the etiology and pathogenesis of Alzheimer's Disease.
  • To integrate metabolomics and methylation analysis for deeper insights into AD.
  • To explore the relationship between epigenetic changes and metabolic alterations in AD.

Main Methods:

  • Utilized targeted LC-MS/MS and 1H NMR for metabolite profiling.
  • Employed Illumina Infinium Methylation EPIC Bead Chip assay for methylation analysis.
  • Analyzed post-mortem brain samples from AD, mild-AD, and control groups.

Main Results:

  • Identified significant differences in metabolite concentrations between AD/mild-AD and control groups.
  • Detected differentially methylated CpGs in individuals with AD and mild-AD compared to controls.
  • Revealed upregulated inflammatory, serotonergic, and sphingolipid metabolic pathways in mild-AD.

Conclusions:

  • Demonstrated an intricate relationship between methylation changes and metabolite concentrations in AD.
  • Highlighted the utility of integrating metabolomics and epigenetics for studying AD.
  • Emphasized the potential of multi-omics approaches for understanding AD pathogenesis.