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Related Experiment Video

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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Wendy Weiqiao Qiu1

  • 1Boston University School of Medicine, BOSTON, MA, USA; Boston University School of Medicine, 352 Beacon Street, Unit#5, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary

Peripheral inflammation and endothelial dysfunction increase Alzheimer's disease (AD) risk. Brachial artery flow-mediated dilation (FMD) can predict AD dementia, with healthier endothelial function linked to lower risk and better brain health.

Area of Science:

  • Neuroscience
  • Cardiovascular Science
  • Gerontology

Background:

  • Peripheral inflammation negatively impacts endothelial function and contributes to Alzheimer's disease (AD) pathogenesis.
  • Brachial artery flow-mediated dilation (FMD) is a key indicator of conduit artery endothelial function.

Purpose of the Study:

  • To investigate the predictive value of FMD for AD dementia risk.
  • To explore the association between endothelial function and AD biomarkers and brain volumes.

Main Methods:

  • Utilized data from 2844 participants in the Framingham Heart Study (FHS) offspring cohort.
  • Assessed baseline FMD measurements, incident dementia/AD, plasma AD biomarkers, and brain volumes over a 17-year follow-up period.

Main Results:

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  • Individuals with normal cognitive function exhibited higher FMD and hyperemic mean flow velocity compared to those with mild cognitive impairment or dementia.
  • Lower FMD and hyperemic mean flow velocity were significantly associated with increased AD dementia risk, even after adjusting for covariates.
  • Higher tertiles of endothelial function markers correlated with lower AD biomarker levels and larger brain volumes.

Conclusions:

  • This study establishes a link between endothelial dysfunction and AD dementia risk in a community cohort.
  • Healthy brain endothelium appears to be a protective factor against cognitive decline and AD development during aging.