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Clinical Manifestations.

Monica Sanches Yassuda1, Luc A Crivelli2, Claudia Kimie Suemoto3

  • 1Universidade de São Paulo, São Paulo, São Paulo, Brazil.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

The Cognitive Function Index (CFI) can help identify individuals with Subjective Cognitive Decline (SCD) in Latin America. This tool shows potential for early cognitive impairment detection in dementia prevention efforts.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Public Health

Background:

  • Subjective Cognitive Decline (SCD) is self-perceived cognitive impairment not evident in standard tests.
  • The Cognitive Function Index (CFI) is a tool to identify individuals with SCD.
  • Limited research on CFI exists in Latin America (LA).

Purpose of the Study:

  • Investigate the association between CFI scores and global cognition in a LA population.
  • Determine if CFI scores can identify individuals with cognitive performance below 1.0 standard deviation (SD) of the mean.

Main Methods:

  • Analysis of 815 participants from the LatAm-FINGERS dementia prevention study.
  • Cognition assessed using the Preclinical Alzheimer Cognitive Composite (PACC-5).
  • CFI scores were correlated with PACC-5 scores; Receiver Operating Characteristic (ROC) analyses were performed.

Main Results:

  • A significant negative association was found between CFI and PACC-5 scores (r = -0.27, p < 0.001).
  • ROC analysis showed an Area Under the Curve (AUC) of 0.71 for CFI in identifying individuals with PACC-5 scores below 1 SD.
  • An optimal CFI cutoff score of 0.36 was suggested.

Conclusions:

  • The CFI can be a valuable addition to cognitive screening protocols for identifying individuals needing further assessment.
  • Integrating CFI into screening strategies in LA may help reduce cognitive health disparities.
  • This approach can advance tailored dementia prevention initiatives specific to LA's challenges.