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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Jieyin Li1, Anqi Li2, Laihong Zhang1

  • 1Institute of Neurological and Psychiatric Disorders, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Lower plasma platelet-derived growth factor receptor-β (PDGFRβ) levels indicate blood-brain barrier (BBB) damage and are associated with Alzheimer's disease (AD) progression, especially in males, suggesting PDGFRβ as a potential plasma biomarker.

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Area of Science:

  • Neuroscience
  • Biomarker Discovery
  • Aging Research

Background:

  • Cerebrospinal fluid (CSF) platelet-derived growth factor receptor-β (PDGFRβ) and CSF/plasma albumin ratio (Qalb) are established blood-brain barrier (BBB) damage biomarkers.
  • The relationship between plasma PDGFRβ and BBB integrity, as well as its association with Alzheimer's disease (AD), remains unclear.

Purpose of the Study:

  • To investigate the association between plasma PDGFRβ levels and BBB damage, indicated by Qalb.
  • To explore the correlation of plasma PDGFRβ with cognitive decline and AD pathology in an aging Chinese cohort.

Main Methods:

  • Plasma PDGFRβ and Qalb were measured in 93 participants with CSF and plasma samples.
  • Plasma PDGFRβ was further assessed in 592 participants across normal control, subjective cognitive decline, mild cognitive impairment, and dementia groups.
  • Associations with Aβ PET, tau PET, MRI-derived measures, and MoCA scores were analyzed.

Main Results:

  • Plasma PDGFRβ negatively correlated with Qalb in the overall cohort and males, suggesting a link to BBB damage.
  • Lower plasma PDGFRβ levels were observed in individuals with mild cognitive impairment and dementia compared to controls.
  • Decreased plasma PDGFRβ was associated with increased amyloid-β (Aβ) and tau PET deposition and lower cognitive scores (MoCA).

Conclusions:

  • Reduced plasma PDGFRβ levels are indicative of blood-brain barrier (BBB) damage.
  • Plasma PDGFRβ may serve as a potential peripheral biomarker for detecting and monitoring BBB leakage in Alzheimer's disease (AD), particularly in males.