Miracle berry for management of cancer and cancer treatment-related adverse effects

Chemotherapy, radiotherapy, and other primary oncological treatments cause nausea, dysgeusia, taste dysfunctions, nutritional insufficiency, and more in millions of cancer patients globally. There is a strong need for finding effective supplementary treatments and naturally derived therapies to supplement care. Synsepalum dulcificum (Schumach. & Thonn.) Daniell (also known as the "miracle berry" or "miracle fruit") has been known to be a strong source of various bioactive phytocompounds.

This work critically examines the available evidence to determine the potential role of miracle berry supplementation in the management of cancer patients and cancer treatment-related adverse effects.

We have provided a brief overview of the phytochemical profile, biological and pharmacological activities, and toxicity/safety of miracle berry-derived agents. Clinical studies on miracle berry supplementation in cancer patients and healthy subjects for conditions or symptoms related to cancer treatment, were analyzed.

Our search includes the analysis of 9 total clinical studies, which highlight the potential of S. dulcificum consumption in aiding oncologic care, as evidenced by its effects on improving sweet taste perception, increasing caloric intake, altering oral/intestinal microbiota, and improving musculoskeletal and dermatologic health. Larger cohorts, intervention standardization, and further trials will further support translation of miracle berry into oncologic care.

While there is limited clinical evidence to elucidate ideal contexts for using miracle berry products for managing cancer patients, the current data show promise for its supplemental use for cancer treatment and care in addressing various health domains.