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Updated: Jan 7, 2026
Minimally Invasive Embryo Transfer and Embryo Vitrification at the Optimal Embryo Stage in Rabbit Model
Published on: May 16, 2019
Clinical efficacy of AdhesioRT-guided personalized embryo transfers: a prospective randomized controlled trial
Mélanie Chow-Shi-Yée1, Eva Kadoch1, Marie-Eve Stebenne1
1Ovo Clinic, Montreal, QC, Canada.
Research Question:
How effective is AdhesioRT in predicting endometrial receptivity, and how does its application affect clinical outcomes, such as pregnancy rates, in the context of personalized embryo transfers (pET)?
Design:
AdhesioRT was employed to evaluate endometrial receptivity in a cohort of patients undergoing infertility assessment. The study included two endometrial biopsies during a substituted frozen embryo transfer cycle after 6 or 8 full days of progesterone treatment, where the gene expression of 10 specific biomarkers was analysed using quantitative reverse transcription polymerase chain reaction. Samples were categorized as receptive, partially receptive or non-receptive. The AdhesioRT group (n = 50) underwent pET guided by AdhesioRT recommendations, while the control group (n = 54) followed the standard clinic protocol.
Results:
AdhesioRT identified a potential shift in the window of implantation (WOI) in 64% of the AdhesioRT group, yet pET led to a lower pregnancy rate compared with the control group (28% vs 61%). Transfers after 6 full days of progesterone treatment, as recommended by AdhesioRT, achieved a 59% pregnancy rate, whereas those with a suggested WOI shift (transfer at a different time point than after 6 full days of progesterone treatment) achieved a 20% pregnancy rate.
Conclusion:
Surprisingly, AdhesioRT-guided embryo transfers did not lead to higher pregnancy rates, indicating that deviating from the standard transfer day (i.e. after 6 full days of progesterone treatment) may reduce the success of embryo implantation.
