In utero and early childhood exposure to per- and polyfluoroalkyl substances and use of antibiotics in children from the Odense Child Cohort: A Danish cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.This study found no link between prenatal or early childhood exposure to per- and polyfluoroalkyl substances (PFAS) and the number of antibiotic prescriptions by age eight. These findings suggest antibiotic prescriptions may not be a specific enough marker for childhood infections in relation to PFAS exposure.
Area Of Science
- Environmental Health
- Pediatric Health
- Toxicology
Background
- Per- and polyfluoroalkyl substances (PFAS) are environmental contaminants linked to increased infectious disease risk.
- Investigating early-life exposure to PFAS and its impact on child health outcomes is crucial.
- The association between PFAS exposure and antibiotic use in children requires further elucidation.
Purpose Of The Study
- To examine the relationship between in utero and early childhood exposure to PFAS and the number of antibiotic prescriptions up to eight years of age.
- To determine if specific PFAS compounds influence antibiotic use in children.
- To assess the utility of antibiotic prescriptions as a marker for infection in studies of environmental exposures.
Main Methods
- Analysis of 2448 singleton mother-child pairs from the Odense Child Cohort, with 1425 included in primary analysis.
- Utilized redeemed antibiotic prescription data from birth to eight years from the Danish National Prescription Registry.
- Employed longitudinal discrete-time Poisson models to assess PFAS associations, with separate analyses for maternal and child PFAS measurements and Multiple Imputation for missing data.
Main Results
- No significant differences in antibiotic prescriptions were observed up to age eight when comparing median and high PFAS concentrations (e.g., PFOA rate ratio 1.01, PFOS 1.08).
- Specific PFAS compounds including PFOA, PFOS, PFNA, PFDA, and PFHxS showed no clear association with the number of antibiotic prescriptions.
- Results indicate a lack of association between measured PFAS levels and antibiotic use in early childhood.
Conclusions
- No association was found between in utero or early childhood PFAS concentrations and the number of antibiotic prescriptions up to eight years of age.
- Antibiotic prescriptions may serve as a non-specific indicator of childhood infections, potentially masking associations with PFAS exposure.
- Further research may be needed to identify more specific biomarkers of infection in relation to environmental exposures.
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