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Clinical Manifestations.

Gabriela Raquel Paz Rivas1, Barbara Loeblein Uebel2, Victória Tizeli Souza3

  • 1Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Subjective cognitive decline (SCD) in cognitively unimpaired individuals is linked to anxiety, not directly to sleep quality. Poor sleep quality in this group correlates with higher anxiety levels, suggesting a complex relationship.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Sleep Medicine

Background:

  • Subjective cognitive decline (SCD) represents self-perceived cognitive impairment in cognitively unimpaired (CU) individuals.
  • SCD is an early indicator in neurodegenerative disease continuum, with a heterogeneous and not fully understood etiology.
  • Sleep disturbances are increasingly implicated in cognitive complaints and objective cognitive decline.

Purpose of the Study:

  • To investigate sleep-related complaints in individuals with SCD.
  • To evaluate the association between sleep quality and cognitive/neuropsychiatric measures in a South-Brazilian cohort.

Main Methods:

  • Included CU individuals aged ≥65 from the BRASCODE cohort with subjective cognitive complaints.
  • Utilized neurocognitive and neuropsychiatric evaluations, including Memory Complaint Scale (MCS), Subjective Cognitive Decline Scale (SCD-S), MMSE, GAI, GDS, PSQI, MBI, and NPI.
  • Analyzed correlations between sleep quality (PSQI) and cognitive/anxiety/depression/behavioral scales at 12-month follow-up.

Main Results:

  • A significant positive correlation was found between Pittsburgh Sleep Quality Index (PSQI) and Geriatric Anxiety Inventory (GAI) scores (p=0.01, rho=0.25).
  • No significant associations were observed between PSQI and SCD scales, MMSE, age, education, or behavioral scales (MBI, NPI).
  • The cohort comprised 100 participants (75% women, median age 71).

Conclusions:

  • Poor sleep quality in CU individuals with SCD from a South-Brazilian cohort is associated with anxiety.
  • Further research is needed to elucidate the intricate relationships between cognition, anxiety, and sleep disturbances.
  • Findings highlight the importance of assessing anxiety in individuals with SCD and sleep complaints.