Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

520
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
520
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

299
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
299
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

364
Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
364
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

436
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
436
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

652
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
652
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

437
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
437

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The dominant role of geriatrics vulnerabilities and comorbidities in readmissions after colorectal surgery: Shifting from "nonmodifiable" to "actionable" risk.

Surgery·2026
Same author

Magnetic Anisotropy Dominates over Physical and Magnetic Structure in Performance of Magnetic Nanoflowers.

Small structures·2026
Same author

Rehospitalization and the Association of Postoperative Delirium With Cognitive Decline in Older Adults.

JAMA internal medicine·2026
Same author

Molecular-Interactions Driven Conjugated Polymer Nanofiber Self-Assembly Toward Greener Fabrication.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

An unusual association of acute acquired comitant esotropia and bilateral idiopathic optic neuritis in two boys: a case series.

Strabismus·2026
Same author

Cognitive Trajectories After Major Surgery in Older Adults and Factors Associated With Severe Decline.

Journal of the American Geriatrics Society·2026

Related Experiment Video

Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K

Clinical Manifestations.

Mfon E Umoh1, Anirudh Sharma1, Jeannie-Marie S Leoutsakos2

  • 1Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Postoperative delirium significantly impacts cognitive decline in older adults after hip fracture repair, particularly affecting those with no prior cognitive impairment. This highlights the importance of preventing delirium to preserve cognitive function in vulnerable elderly patients.

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Related Experiment Videos

Last Updated: Jan 7, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

16.4K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

20.7K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

6.1K

Area of Science:

  • Geriatric Medicine
  • Neuroscience
  • Cognitive Health

Background:

  • Delirium is an acute cognitive disorder in older adults, linked to adverse outcomes including future cognitive decline.
  • Hip fracture repair (HFR) patients are at risk for postoperative delirium.
  • The long-term cognitive impact of delirium in HFR patients requires further investigation.

Purpose of the Study:

  • To determine the 1-year cognitive impact of postoperative delirium in patients undergoing hip fracture repair (HFR).
  • To test the hypothesis that delirium has a greater cognitive impact on individuals without baseline cognitive impairment compared to those with pre-existing impairment.

Main Methods:

  • Analysis of cognitive assessments from 200 HFR patients (age ≥65, MMSE ≥15) from the STRIDE trial.
  • Adjudication of delirium status and Clinical Dementia Rating (CDR) by a consensus panel.
  • Longitudinal assessment of Mini-Mental State Exam (MMSE) scores at baseline, 1 month, and 1 year using a random-intercept linear spline model.

Main Results:

  • Delirium occurred in 36.5% of HFR patients.
  • Patients experiencing delirium showed a greater rate of MMSE decline over 1 year, especially those without baseline cognitive impairment (CDR=0).
  • Greater delirium severity correlated with faster MMSE decline in the cognitively unimpaired subgroup.

Conclusions:

  • Postoperative delirium and its severity significantly affect cognitive trajectories in older adults post-HFR.
  • Cognitively unimpaired individuals appear most vulnerable to the long-term cognitive consequences of delirium.
  • Preventing delirium is crucial for maintaining cognitive function in elderly patients undergoing hip fracture surgery.