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Sodium-glucose co-transporter 2 inhibition improves age-dependent kidney microvascular rarefaction

Anastasia Paulmann1, Matthew D Cox2, Tom Boewer1

  • 1Mount Desert Island Biological Laboratory (MDIBL), Bar Harbor, Maine, USA; Division of Nephrology and Hypertension, Hannover Medical School (MHH), Hannover, Germany.

Kidney International
|December 25, 2025
PubMed
Summary

Aging kidneys show vascular damage and functional decline. Dapagliflozin (SGLT2i) treatment in killifish preserved kidney microvasculature, reduced albuminuria, and maintained a youthful transcriptome, suggesting vascular protection.

Keywords:
African turquoise killifishSGLT2 inhibitioncell-cell communicationkidney agingmetabolic shiftmicrovascular rarefaction

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