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Clinical Manifestations.

Oriel J Feldman1,2, Myuri Ruthirakuhan2, Nathan Herrmann3,4,5

  • 1University of Toronto, Toronto, ON, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Nabilone effectively treats agitation in Alzheimer

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Area of Science:

  • Neuroscience
  • Geriatrics
  • Pharmacology

Background:

  • Agitation is a common neuropsychiatric symptom (NPS) in Alzheimer's disease (AD).
  • Previous trials indicated nabilone's efficacy in managing agitation in AD patients.
  • Identifying predictors of nabilone response can optimize treatment strategies.

Purpose of the Study:

  • To determine clinical characteristics that predict a positive response to nabilone for agitation in Alzheimer's disease patients.

Main Methods:

  • A priori identification of 22 potential clinical predictors.
  • Analysis of predictors for improvement on the Cohen-Mansfield Agitation Inventory (CMAI).
  • Univariate and multivariate regression analyses to model treatment interactions and identify significant predictors.

Main Results:

  • Nabilone was more effective in patients with higher standardized Mini-Mental State Exam (sMMSE) scores (≥6).
  • Predictors of positive response included higher levels of pain, apathy, and appetite/eating changes.
  • Patients not taking cholinesterase inhibitors (ChEIs) also showed greater benefit.

Conclusions:

  • Patients with less cognitive impairment, experiencing pain, apathy, and appetite changes, and not on ChEIs, are most likely to benefit from nabilone.
  • These identified predictors may help clinicians personalize nabilone treatment for agitation in AD.
  • Further validation with Phase 3 data is recommended to confirm these findings.