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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
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Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Weitao Yu1, Sheng Zhang2

  • 1Hangzhou Normal University, Hangzhou, Zhejiang, China.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Swept Source Optical Coherence Tomography Angiography (SS-OCTA) shows promise for screening mild cognitive impairment (MCI) in cerebral small vessel disease (CSVD) patients. Macular perfusion area measurements using SS-OCTA are effective MCI screening markers.

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Area of Science:

  • Ophthalmology
  • Neurology
  • Medical Imaging

Background:

  • Cerebral small vessel disease (CSVD) is associated with mild cognitive impairment (MCI).
  • Developing effective screening tools for MCI in CSVD patients is crucial.
  • Swept Source Optical Coherence Tomography Angiography (SS-OCTA) offers high-resolution imaging of ocular vasculature.

Purpose of the Study:

  • To develop and validate novel biomarkers for screening MCI in CSVD patients.
  • To evaluate the efficacy of SS-OCTA in detecting MCI-related changes.
  • To identify specific SS-OCTA parameters indicative of MCI in CSVD.

Main Methods:

  • Prospective recruitment of participants with MCI and normal cognition (NC) from the Dream-10 and FRESH-CSVD studies.
  • Exclusion of Alzheimer's disease (AD) patients using plasma biomarkers.
  • Categorization into development and validation cohorts; LASSO regression for marker selection and temporal validation.

Main Results:

  • 102 participants enrolled (59.8% MCI).
  • Development cohort identified left transverse temporal gyrus volume, right choroid plexus volume, and macular perfusion area (0-3mm and 0-6mm) as MCI markers.
  • Validation cohort confirmed 0-3mm and 0-6mm macular choriocapillaris perfusion area (CCPA) as superior MCI markers (AUC > 0.83).

Conclusions:

  • SS-OCTA, particularly macular CCPA, demonstrates significant potential for screening MCI in CSVD patients.
  • These findings suggest SS-OCTA can serve as a non-invasive tool for early MCI detection in this population.
  • Further research may refine SS-OCTA's role in managing CSVD-related cognitive decline.