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Updated: Jan 7, 2026
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
Published on: January 28, 2014
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Biomarkers
Jemma Hazan1, Kathy Y Liu2, Robert Howard3
1University College London, London, London, United Kingdom.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
Summary
Plasma phosphorylated tau (p-tau) levels increase with age, unaffected by amyloid status. This finding is crucial for establishing reliable blood biomarker reference ranges in Alzheimer's disease research.
Area of Science:
- Neuroscience
- Biochemistry
- Gerontology
Background:
- Plasma phosphorylated tau (p-tau) is a potential Alzheimer's disease (AD) blood biomarker.
- CSF examination is invasive, limiting its use in memory services.
- The influence of aging on plasma p-tau requires further investigation.
Purpose of the Study:
- To review the correlation between age and plasma p-tau levels.
- To analyze the impact of age, creatinine, BMI, sex, and race on plasma p-tau181 using ADNI data.
Main Methods:
- Systematic literature review.
- Analysis of Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset.
- Statistical modeling to assess fixed effects on plasma p-tau181.
Main Results:
- Plasma p-tau181 positively correlated with age, creatinine, and minority ethnicity.
- Plasma p-tau181 negatively correlated with baseline BMI.
- The age-p-tau181 correlation was independent of creatinine, BMI, and race.
Conclusions:
- Age is a significant factor influencing plasma p-tau181 levels.
- Recommendations are provided to address knowledge gaps in future biomarker studies.
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