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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

749
Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
749
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

516
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
516

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Related Experiment Video

Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
07:20

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies

Published on: January 28, 2014

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Biomarkers.

Jemma Hazan1, Kathy Y Liu2, Robert Howard3

  • 1University College London, London, London, United Kingdom.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Plasma phosphorylated tau (p-tau) levels increase with age, unaffected by amyloid status. This finding is crucial for establishing reliable blood biomarker reference ranges in Alzheimer's disease research.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Gerontology

Background:

  • Plasma phosphorylated tau (p-tau) is a potential Alzheimer's disease (AD) blood biomarker.
  • CSF examination is invasive, limiting its use in memory services.
  • The influence of aging on plasma p-tau requires further investigation.

Purpose of the Study:

  • To review the correlation between age and plasma p-tau levels.
  • To analyze the impact of age, creatinine, BMI, sex, and race on plasma p-tau181 using ADNI data.

Main Methods:

  • Systematic literature review.
  • Analysis of Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset.
  • Statistical modeling to assess fixed effects on plasma p-tau181.

Main Results:

  • Plasma p-tau181 positively correlated with age, creatinine, and minority ethnicity.
  • Plasma p-tau181 negatively correlated with baseline BMI.
  • The age-p-tau181 correlation was independent of creatinine, BMI, and race.

Conclusions:

  • Age is a significant factor influencing plasma p-tau181 levels.
  • Recommendations are provided to address knowledge gaps in future biomarker studies.