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Drug Development.

Adam I Birnbaum1, Kristin Harkins2, Jason Karlawish2

  • 1University of California, Irvine, Irvine, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Identifying individuals willing to join Alzheimer's disease (AD) clinical trials is key. Favorable research attitudes and AD concerns predict willingness, with few racial/ethnic differences, except in low-incentive trials.

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Area of Science:

  • Neuroscience
  • Clinical Trials
  • Public Health

Background:

  • Alzheimer's disease (AD) clinical trial recruitment faces significant challenges.
  • Identifying individuals predisposed to participate is crucial for effective recruitment strategies.

Purpose of the Study:

  • To assess factors influencing willingness to participate in preclinical AD clinical trials.
  • To examine willingness across diverse racial and ethnic groups under varying incentive conditions.

Main Methods:

  • Participants rated willingness to join trials with high, medium, or low incentives on a 7-point Likert scale.
  • Classification and Regression Trees (CARTs) and random forests were used to identify predictive characteristics.
  • Willingness was analyzed across racial and ethnic groups, including Hispanic, Non-Hispanic White, Non-Hispanic Black, and Non-Hispanic Asian participants.

Main Results:

  • Overall willingness was similar across racial and ethnic groups in high-incentive scenarios.
  • Favorable research attitudes (Research Attitudes Questionnaire - RAQ) and AD concerns predicted higher willingness in all scenarios.
  • Higher income predicted willingness in low-incentive scenarios; cognitive measures were most predictive for Hispanic participants in some scenarios.

Conclusions:

  • The RAQ and AD concerns are potentially low-cost tools for identifying willing participants for AD trials.
  • Minimal differences in willingness were observed across racial and ethnic groups.
  • Further research is recommended to explore the RAQ's relationship with willingness among Hispanic individuals.