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Drug Development.

Sana Praween1, Sukriti Vishwas2

  • 1School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar, Punjab, Jalandhar, Punjab, India.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Rosmarinic acid (RA) shows promise for Alzheimer's disease (AD) treatment, reducing amyloid plaques and improving cognition. Further clinical trials are needed to confirm its efficacy as a supportive therapy for AD.

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Area of Science:

  • Neuroscience
  • Pharmacology
  • Biochemistry

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder marked by cognitive decline, driven by neuronal degeneration and characterized by oxidative stress, neuroinflammation, and amyloid-beta plaque accumulation.
  • Current AD treatments have limited efficacy, necessitating research into novel therapeutic agents.
  • Rosmarinic acid (RA), a natural polyphenol, exhibits antioxidant, anti-inflammatory, anti-amyloid, and anti-apoptotic properties, suggesting potential therapeutic benefits for AD.

Purpose of the Study:

  • To review preclinical and clinical evidence on the efficacy of Rosmarinic acid (RA) in treating Alzheimer's disease (AD).
  • To evaluate RA's effects on AD hallmarks, including cognitive function, neuroinflammation, and oxidative stress.

Main Methods:

  • A comprehensive review of in vitro and in vivo studies, as well as clinical trials, investigating Rosmarinic acid (RA) for Alzheimer's disease (AD) treatment.
  • Database searches were conducted to identify relevant studies examining RA's impact on AD models and human subjects.

Main Results:

  • Preclinical and clinical data indicate that RA possesses significant anti-inflammatory, antioxidant, and neuroprotective effects beneficial for mitigating AD pathology.
  • In animal models, RA administration reduced amyloid-beta plaque deposition, decreased oxidative stress markers, and enhanced cognitive performance.
  • Limited clinical studies suggest positive trends in cognitive improvement and symptom management with RA supplementation, positioning it as a potential supportive treatment for AD.

Conclusions:

  • Rosmarinic acid (RA) shows considerable promise as a therapeutic agent for Alzheimer's disease (AD) due to its multifaceted mechanisms of action.
  • RA's anti-inflammatory, antioxidant, and neuroprotective properties may help alleviate key pathological features of AD.
  • While further clinical trials are essential to establish efficacy and optimal dosage, RA could serve as a valuable adjunct therapy for managing Alzheimer's disease.