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Clinical Manifestations.

Pontus Tideman1,2, Linda Karlsson3, Olof Strandberg4

  • 1Clinical Memory Research Unit, Lund University, Lund, Sweden.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

A new digital cognitive test (BioCog) accurately detects cognitive impairment in primary care settings. Combined with a blood test, it identifies Alzheimer's disease (AD) with high precision, aiding early diagnosis.

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Area of Science:

  • Neurology
  • Digital Health
  • Biomarkers

Background:

  • Emerging Alzheimer's disease (AD) therapies necessitate efficient patient identification.
  • Primary care settings face challenges in timely cognitive assessment due to time constraints and variable expertise.
  • Existing cognitive tests have limitations in administration and interpretation consistency.

Purpose of the Study:

  • To develop and evaluate a brief, self-administered digital cognitive battery (BioCog) for detecting cognitive impairment.
  • To assess the utility of BioCog, alone and combined with blood biomarkers, for identifying AD in primary care.

Main Methods:

  • BioCog assesses memory, processing speed, and orientation in 10-15 minutes.
  • A logistic regression model with cutoffs was developed and validated in Swedish cohorts (memory clinic n=223, primary care n=403).
  • Primary outcome was objectively verified cognitive impairment using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS).

Main Results:

  • BioCog achieved 85% accuracy in predicting cognitive impairment in primary care, outperforming physicians (73%).
  • Accuracy increased to 90% with two cutoffs and surpassed standard tests (MMSE, MoCA, Mini-Cog, CANTAB).
  • Combined BioCog and blood test (PrecitivityAD2™) identified biomarker-verified AD with 90% accuracy, superior to clinical evaluation (70%) or blood test alone (80%).

Conclusions:

  • BioCog is a brief, self-administered digital test effective for detecting cognitive impairment in primary care.
  • The combination of BioCog and a blood test accurately identifies clinical AD in primary care settings.