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Clinical Manifestations.

Alexandra M Reed1, Andrew Hooyman2, Edward Ofori3

  • 1Arizona State University, Tempe, AZ, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Gait speed may indicate Alzheimer's disease risk factors in diverse older adults, but it was not directly linked to amyloid pathology. Further research is needed to explore its connection to social determinants of health.

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Area of Science:

  • Neurology
  • Gerontology
  • Public Health

Background:

  • Alzheimer's disease (AD) biomarkers are understudied in Hispanic/Latino populations, who face higher risks and later diagnoses.
  • Cognitive screening tools often lack equity across diverse demographic groups.
  • Performance-based motor assessments, like gait speed, may offer more equitable early screening for AD risk.

Purpose of the Study:

  • To compare the relationship between gait speed and amyloid levels in cognitively unimpaired Hispanic/Latino and non-Hispanic White older adults.
  • To investigate gait speed as a potential equitable biomarker for Alzheimer's disease risk across ethnicities.

Main Methods:

  • The study analyzed 597 cognitively unimpaired adults (46.66% Hispanic) from the Healthy Aging Brain Study-Health Disparities.
  • Multiple linear regression examined gait time in relation to ethnicity, age, sex, diabetes, hypertension, and amyloid status.
  • Amyloid positivity was determined using florbetaben SUVR threshold; gait time was measured in seconds.

Main Results:

  • Non-Hispanic White adults had significantly lower gait times than Hispanic/Latino adults, despite being older.
  • Differences in gait time between ethnic groups were not explained by diabetes, hypertension, or amyloid levels.
  • The overall regression model was significant but explained little variance (adj R² = 0.07).

Conclusions:

  • Gait speed may reflect risk factors for Alzheimer's disease and related dementias but is not directly associated with AD-specific amyloid pathology.
  • Gait speed's potential as an equitable screening tool requires further investigation, particularly regarding social determinants of health.