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Clinical Manifestations.

Zarui A Melikyan1, Zeinah Al-Darsani2, Michael A Yassa2

  • 1University of California Irvine, Irvine, CA, USA.

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|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Long sleep is linked to reduced brain volumes in very old adults. In amyloid-negative individuals, long sleep correlated with lower white matter volume, while in amyloid-positive individuals, it was linked to lower gray matter volume.

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Area of Science:

  • Neuroimaging
  • Sleep Medicine
  • Gerontology

Background:

  • Previous studies indicate a link between prolonged sleep duration and reduced brain volumes in older adults.
  • The influence of amyloid pathology on this association in cognitively normal individuals remains unclear.

Purpose of the Study:

  • To investigate the relationship between self-reported sleep duration and brain MRI volumetric measures in cognitively unimpaired individuals aged 90 and above.
  • To determine if amyloid status modifies the association between sleep duration and brain structure.

Main Methods:

  • Utilized data from The 90+ Study, including cognitively normal participants with brain MRI and amyloid PET scans.
  • Sleep duration was self-reported and categorized (<8, 8=reference, >8 hours).
  • Analyzed supratentorial gray matter, white matter, hippocampus, and white matter hyperintensities volumes using multiple linear regression, stratified by amyloid status.

Main Results:

  • The study included 104 participants (mean age 93 years), with 36% being amyloid-positive.
  • Among amyloid-negative participants, those sleeping >8 hours had significantly lower white matter volume compared to the reference group (p=0.03).
  • Among amyloid-positive participants, those sleeping >8 hours had significantly lower gray matter volume compared to the reference group (p=0.02).

Conclusions:

  • Prolonged sleep duration is associated with reduced white matter volume in amyloid-negative, cognitively normal older adults.
  • In amyloid-positive, cognitively normal older adults, long sleep duration is associated with reduced gray matter volume.
  • These findings suggest that the relationship between long sleep and brain structure in aging may be influenced by underlying amyloid pathology.