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Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

David C Zhu1, Josh Hubert2, Norman Scheel2

  • 1Albert Einstein College of Medicine, Bronx, NY, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

In older adults, higher blood pulse pressure is linked to increased arterial blood flow pulsatility. Conversely, a faster heart rate is associated with reduced brain tissue pulsatility.

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Area of Science:

  • Cardiovascular research
  • Neuroimaging
  • Gerontology

Background:

  • The HIPAC Trial investigates links between blood pressure, heart rate, and intracranial pulsatility in older adults.
  • Understanding these relationships is crucial for managing cerebrovascular health in aging populations.

Purpose of the Study:

  • To examine the correlations between blood pressure, heart rate, and both arterial blood flow pulsatility and brain tissue pulsatility.
  • To quantify these relationships using advanced MRI techniques.

Main Methods:

  • Utilized 3T MRI (GE Discovery 3T MR750W) on 85 older adults (65 ± 6 years).
  • Employed 2D CINE Phase Contrast (PC) MRI to measure blood flow and brain tissue pulsatility.
  • Quantified pulse pressure (PP), heart rate, internal carotid artery (ICA) pulsatility, and global brain tissue pulsatility.

Main Results:

  • Positive correlation found between pulse pressure and ICA blood flow pulsatility (R = 0.414-0.466, P < 10⁻⁴).
  • Negative correlation observed between heart rate and global brain tissue pulsatility (R = -0.452 to -0.830, P < 10⁻⁵).
  • Heart rate negatively correlated with cerebral blood volume per cardiac cycle (CBV-C), which positively correlated with brain tissue pulsatility.

Conclusions:

  • Blood pulse pressure positively correlates with arterial blood flow pulsatility in older adults.
  • Heart rate negatively correlates with brain tissue pulsatility in this demographic.