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Clinical Manifestations.

Ileana De Anda-Duran1, Phillip H Hwang2, Laura A Salciunas3

  • 1Celia Scott Weatherhead Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

The Digital Assessment of Cognition (DAC) shows strong validity against traditional tests, accurately identifying cognitive impairments. Its ease of use makes it ideal for early detection of memory and executive function decline.

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Digital Health

Background:

  • The Digital Assessment of Cognition (DAC) is a brief, self-administered digital neuropsychological tool.
  • DAC assesses multiple cognitive domains, including episodic and working memory.
  • This study validates DAC against established paper-and-pencil neuropsychological tests.

Purpose of the Study:

  • To evaluate the construct and criterion validity of the DAC.
  • To determine the relationship between DAC metrics and traditional neuropsychological measures.
  • To assess DAC's utility in classifying cognitive impairment.

Main Methods:

  • 171 memory clinic patients were assessed using the DAC.
  • K-means cluster analysis categorized patients into diagnostic groups (MCI subtypes, dementia, normal cognition).
  • A subset of patients (n=107) underwent traditional paper-and-pencil testing across five cognitive domains.

Main Results:

  • The DAC and paper-and-pencil classifications showed 89% concordance.
  • DAC memory and executive indices significantly correlated with corresponding paper-and-pencil measures (p < 0.001).
  • Multinomial logistic regression confirmed DAC's ability to classify patients across cognitive impairment levels.

Conclusions:

  • The DAC demonstrates strong construct and criterion validity.
  • Its efficiency and ease of use support its role as a frontline cognitive screening tool.
  • DAC can effectively identify individuals with emergent cognitive impairment.