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Related Experiment Video

Updated: Jun 25, 2026

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Single-Crystalline-Mesoporous TiN Nanosheets Free of Intrinsic Raman Scattering for Highly Sensitive Surface-Enhanced

Yang Yu^1,2, Yijing Zong¹, Tao Li¹

¹Key Laboratory of Consumer Product Quality Safety Inspection and Risk Assessment for State Market Regulation, Chinese Academy of Quality and Inspection & Testing, Beijing 100176, China.

Analytical Chemistry

|December 25, 2025

Summary

Researchers developed novel single-crystalline mesoporous titanium nitride (SCM-TiN) nanosheets for surface-enhanced Raman spectroscopy (SERS). These nonmetallic SERS substrates eliminate background interference, offering enhanced sensitivity and performance.

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Area of Science:

Materials Science
Nanotechnology
Spectroscopy

Background:

Nonmetallic surface-enhanced Raman spectroscopy (SERS) substrates often suffer from intrinsic Raman scattering, causing background interference.
Metal-based SERS substrates lack intrinsic signals but can be costly or prone to corrosion.

Purpose of the Study:

To synthesize novel single-crystalline mesoporous (SCM) titanium nitride (TiN) nanosheets as a nonmetallic SERS substrate.
To overcome the limitations of existing nonmetallic SERS substrates by eliminating intrinsic Raman signals.

Main Methods:

A mixed-molten-salt nitridation strategy using inert (KCl) and reactive (ZnCl2) salts was employed.
In situ formation of a Zn3N2 thin layer facilitated SCM-TiN nanosheet formation and suppressed sintering.

Main Results:

Successfully synthesized 2 nm thick SCM-TiN nanosheets free of intrinsic Raman signals.
Achieved an ultrahigh Raman enhancement factor of 2.71 × 10^8 and an ultralow detection limit of 2.0 × 10^-13 M.
Demonstrated excellent signal reproducibility and durability in corrosive environments.

Conclusions:

SCM-TiN nanosheets serve as a high-performance, nonmetallic SERS substrate with no background interference.
This work presents a new strategy for designing advanced SERS substrates by eliminating intrinsic signal noise.