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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Tzung-Jeng Hwang1, Cho-Hsiang Yang2, Yi-Ting Lin3

  • 1National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Neuropsychiatric symptoms can predict cognitive decline. The Mild Behavioral Impairment Checklist (MBI-C) ratings differ based on who provides the information (self, informant, or researcher), impacting assessments for conditions like Mild Behavioral Impairment (MBI).

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Area of Science:

  • Gerontology
  • Neuroscience
  • Psychiatry

Background:

  • Neuropsychiatric symptoms are potential early indicators of cognitive decline and dementia.
  • The Mild Behavioral Impairment Checklist (MBI-C) assesses neuropsychiatric changes but may be subject to rating biases.
  • Discrepancies in MBI-C ratings can arise from different information sources.

Purpose of the Study:

  • To investigate differences in Mild Behavioral Impairment Checklist (MBI-C) ratings among self-reports, informant reports, and researcher evaluations.
  • To determine if respondent perspectives influence MBI-C scores in individuals with or at risk for cognitive impairment.

Main Methods:

  • 123 participants with Mild Behavioral Impairment (MBI) were recruited, including those with pure MBI and those with MBI and mild cognitive impairment (MCI).
  • Participants, their informants, and researchers completed the MBI-C.
  • Researcher evaluations, based on participant and informant data, served as the gold standard for MBI identification.

Main Results:

  • Significant differences in MBI-C scores were found across self, informant, and researcher ratings in the decreased motivation, affective dysregulation, and social inappropriateness domains.
  • Self and researcher ratings were higher for decreased motivation compared to informant ratings.
  • Researcher ratings were higher for affective dysregulation than informant ratings, while informant ratings were higher for social inappropriateness than self-ratings.

Conclusions:

  • Respondent perspectives significantly influence Mild Behavioral Impairment Checklist (MBI-C) scores.
  • Clinicians must consider potential discrepancies between self, informant, and researcher ratings when interpreting MBI-C results.
  • Caution is advised when using MBI-C data from various sources for diagnosing or monitoring cognitive decline.