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Published on: September 20, 2018
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Clinical Manifestations.
Lucía Pérez-Blanco1,2,3, Fátima Fernández-Feijoo1,2,3, Sonali Arora1,2,3
1Applied Cognitive Neuroscience and Psychogerontology group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
Summary
Memory complaints, assessed by the Memory Failure of Everyday (MFE) questionnaire, can predict cognitive decline. Informant reports are more sensitive for detecting worsening cognition, while self-reports better identify stable cognitive function.
Area of Science:
- Gerontology
- Cognitive Science
- Neurology
Background:
- Subjective memory complaints are a potential risk factor for cognitive impairment and dementia.
- Early identification of individuals at risk is crucial for timely intervention.
Purpose of the Study:
- To evaluate the predictive value of self- and informant-reported memory complaints for cognitive decline.
- To compare the accuracy of participant versus informant reports in identifying cognitive changes.
Main Methods:
- The Memory Failure of Everyday (MFE) questionnaire was administered to cognitively unimpaired older adults and their informants.
- Longitudinal data from 130 older adults and 127 informants were analyzed.
- Receiver Operating Characteristic (ROC) analyses were used to assess the discriminative ability of MFE scores.
Main Results:
- Both self- and informant-reported MFE scores showed significant, albeit modest, predictive value (Area Under the Curve).
- Informant reports demonstrated higher sensitivity (0.63) in identifying participants who worsened.
- Self-reports showed higher specificity (0.92) in identifying stable participants.
Conclusions:
- Memory complaints, as measured by the MFE, have predictive value for cognitive decline.
- Informant reports are more sensitive for detecting early signs of cognitive worsening.
- Self-reports are more specific in identifying individuals with stable cognitive function.
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