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Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Shuo Ni1, Jiaxin Yue2, Yonggand Shi3

  • 1University of Southern California, Los Angeles, CA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Second-generation tau PET tracers like PI-2620 show promise for evaluating subcortical tau pathology in Alzheimer's disease (AD). Ethnicity influences these tau PET signals, particularly in the amygdala for non-Hispanic White individuals.

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Area of Science:

  • Neuroimaging
  • Neurology
  • Alzheimer's Disease Research

Background:

  • First-generation tau PET tracers (e.g., AV-1451) have limitations due to off-target binding in subcortical regions.
  • Second-generation tracers (e.g., PI-2620, MK-6240) offer improved specificity for subcortical tau pathology.
  • Evaluating the utility of novel tau PET tracers in subcortical Alzheimer's disease (AD) research is crucial.

Purpose of the Study:

  • To assess the efficacy of the PI-2620 tau PET tracer in detecting subcortical tau pathology in Alzheimer's disease (AD).
  • To investigate the influence of ethnicity on subcortical tau PET signals in cognitively unimpaired (CU) and cognitively impaired (CI) individuals.
  • To examine differences in tau PET signal across diagnostic categories and ethnic groups within specific subcortical brain structures.

Main Methods:

  • Utilized tau PET data from the PI-2620 tracer in the Health and Aging Brain Study: Health Disparities (HABS-HD) cohort.
  • Included 1,492 participants (1097 CU, 395 CI) with T1-weighted MRI and tau PET imaging, encompassing diverse ethnic groups.
  • Calculated mean Standardized Uptake Value Ratio (SUVR) for subcortical regions (thalamus, caudate, putamen, etc.) using FreeSurfer segmentation.

Main Results:

  • Significant differences in tau SUVR were found in the caudate, hippocampus, and amygdala across diagnostic categories.
  • Ethnic variations in subcortical tau PET signals were observed between cognitively unimpaired and impaired groups.
  • Non-Hispanic White participants showed significant differences in the putamen, hippocampus, and amygdala; Black participants in the caudate; and Hispanic participants in the amygdala.

Conclusions:

  • Ethnicity significantly impacts subcortical tau PET signals in both cognitively unimpaired and impaired individuals.
  • The PI-2620 tracer demonstrates potential for evaluating subcortical tau pathology in diverse populations.
  • Specific subcortical regions, like the amygdala, show differential tau accumulation influenced by ethnicity in Alzheimer's disease.