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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
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Updated: Jan 7, 2026

Dried Blood Spot Collection of Health Biomarkers to Maximize Participation in Population Studies
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Biomarkers.

Maryam Ghahremani1, Rebeca Leon1, Eric E Smith1,2

  • 1Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Mild behavioral impairment (MBI) is linked to higher plasma p-tau217 levels, suggesting MBI may indicate Alzheimer's disease (AD) proteinopathies. This finding supports MBI's role in early AD detection and risk stratification.

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Area of Science:

  • Neuroscience
  • Biomarkers
  • Gerontology

Background:

  • The 2024 NIA-AA criteria define Alzheimer's Disease (AD) using amyloid-beta and tau biomarkers.
  • Mild behavioral impairment (MBI), characterized by persistent neuropsychiatric symptoms, may precede cognitive decline and indicate dementia risk.
  • The association between MBI and plasma p-tau217, a novel blood biomarker for AD pathology, is currently unexplored.

Purpose of the Study:

  • To investigate the association between MBI and plasma p-tau217 levels in older adults.
  • To explore MBI as a potential early indicator of AD-related pathology using plasma p-tau217.

Main Methods:

  • Assessed neuropsychiatric symptoms (NPS) using the Neuropsychiatric Inventory to determine MBI status over two visits.
  • Utilized linear and logistic regression to model the association between MBI status and plasma p-tau217 levels.
  • Adjusted models for age, sex, education, and cognitive diagnosis in participants from the Alzheimer's Disease Neuroimaging Initiative.

Main Results:

  • Participants with MBI exhibited significantly higher plasma p-tau217 levels compared to those without MBI.
  • Individuals with MBI showed increased odds of having elevated (positive) plasma p-tau217 levels.
  • The study included 101 participants (mean age 72.0±6.5 years; 44.6% female; 50.5% with mild cognitive impairment).

Conclusions:

  • MBI is associated with elevated plasma p-tau217, supporting its role in representing AD proteinopathies.
  • MBI assessment may aid in early AD detection and risk stratification for clinical trials.
  • Findings highlight MBI's potential utility in identifying individuals with biomarker positivity for AD.