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Yousef Addassi1, Harrison Taylor2, Alexa McDermott2

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Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
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Lactobacillus postbiotics (Lp-PBx) effectively restored mobility in a Drosophila model of Alzheimer's disease (AD), offering a promising alternative to probiotics. These findings highlight Lp-PBx as a practical therapeutic option for AD-related mobility deficits.

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Area of Science:

  • Neuroscience
  • Microbiology
  • Genetics

Background:

  • Gut microbiota dysbiosis is linked to Alzheimer's disease (AD) pathogenesis.
  • Lactobacillus probiotics show therapeutic potential in AD by modulating the gut microbiome.
  • Lactobacillus postbiotics offer advantages over probiotics, including stability and safety, but their efficacy in AD is understudied.

Purpose of the Study:

  • To compare the effectiveness of Lactobacillus probiotics and postbiotics in mitigating behavioral deficits in a Drosophila model of AD.
  • To evaluate the impact of Lactobacillus plantarum (Lp) and its postbiotic fraction (Lp-PBx) on mobility and memory in AD model flies.

Main Methods:

  • A Drosophila model overexpressing amyloid precursor protein was used.
  • Flies were administered Lp or Lp-PBx via sucrose solution for two weeks.
  • Locomotion was assessed using a negative geotaxis assay, and memory was evaluated through an aversive phototaxic suppression assay.

Main Results:

  • Untreated AD flies exhibited significant mobility impairments compared to controls.
  • Administration of Lp or Lp-PBx restored mobility in AD flies to levels comparable to controls.
  • Food intake analysis revealed differences in consumption between Lp and Lp-PBx groups in males, with memory assays still ongoing.

Conclusions:

  • Lactobacillus plantarum postbiotics (Lp-PBx) are a viable alternative to probiotics for managing mobility deficits in an AD Drosophila model.
  • The palatability of Lp-PBx facilitates administration, presenting a practical therapeutic strategy.
  • Further research is needed to confirm these findings and explore memory effects.