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Olayemi Philemon Aro1, Opeyemi Babatunde Ogunsuyi2, Ganiyu Oboh3

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Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary

Tamarind seeds show promise in combating diabetes-related complications and neurodegeneration. Supplementation reduced oxidative stress and improved metabolic markers in a diabetes model, suggesting potential benefits for Alzheimer's disease (AD) prevention.

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Area of Science:

  • Metabolic disorders
  • Neurodegenerative diseases
  • Plant-based therapeutics

Background:

  • Diabetes mellitus is a significant risk factor for Alzheimer's disease (AD), sharing common pathological pathways like insulin resistance and oxidative stress.
  • Hyperglycemia exacerbates cognitive decline by promoting amyloid-beta and tau pathologies, highlighting the need for interventions.
  • Plant-based compounds with antioxidant and metabolic benefits offer potential therapeutic avenues for managing diabetes and AD.

Purpose of the Study:

  • To investigate the efficacy of tamarind seeds in mitigating metabolic stress and oxidative damage associated with diabetes.
  • To evaluate the potential of tamarind seed supplementation as a therapeutic strategy for conditions linking diabetes and neurodegeneration, such as AD.

Main Methods:

  • A study involving six groups of cockroaches, including a control group and streptozotocin (STZ)-induced diabetic models.
  • Administration of raw or fermented tamarind seeds at varying concentrations (0.5% and 1%) to STZ-induced groups.
  • Analysis of brain homogenates for glucose, triglyceride, reactive oxygen species (ROS), and total thiol levels to assess metabolic and oxidative status.

Main Results:

  • STZ-induced diabetes led to significant increases in glucose and ROS, and a decrease in total thiol levels, indicating oxidative stress.
  • Tamarind seed treatment effectively reduced ROS and glucose levels while increasing total thiol content, demonstrating antioxidant and metabolic-modulating effects.
  • Tamarind seed supplementation also improved survival rates in the treated diabetic cockroach groups.

Conclusions:

  • Tamarind seed supplementation successfully mitigated metabolic stress and oxidative damage, key factors in both diabetes and Alzheimer's disease progression.
  • These findings highlight the therapeutic potential of tamarind seeds in managing neuroprotective pathways relevant to AD in diabetic contexts.
  • Further investigation is warranted to explore tamarind seeds' effects on amyloid-beta, tau pathology, and neuroinflammation in diabetic neurodegeneration models.