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Clinical Manifestations.

Eleni Palpatzis1,2,3, Mahnaz Shekari2, Muge Akinci2,3,4

  • 1Global Health Institute Barcelona (ISGlobal), Barcelona, Spain.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Faster amyloid-beta (Aβ) accumulation in brain regions involved in emotional processing may increase vulnerability to post-traumatic stress disorder (PTSD) symptoms. This accelerated Aβ buildup is particularly linked to intrusion symptoms, suggesting a role in emotional regulation difficulties.

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Area of Science:

  • Neuroscience
  • Alzheimer's Disease Research
  • Mental Health

Background:

  • Mental health symptoms are increasingly recognized as early indicators of Alzheimer's Disease (AD).
  • The neurological underpinnings connecting AD pathology to mental health conditions like post-traumatic stress disorder (PTSD) remain unclear.
  • This study investigates a regional vulnerability hypothesis concerning amyloid-beta (Aβ) accumulation in AD-vulnerable brain regions associated with emotional processing.

Purpose of the Study:

  • To examine the association between the rate of regional Aβ accumulation in specific brain areas and PTSD symptomatology after the COVID-19 pandemic.
  • To test whether early Aβ deposition in emotion-processing regions correlates with the severity of PTSD symptoms.

Main Methods:

  • Utilized data from 628 cognitively unimpaired individuals from the ALFA study, assessing post-pandemic PTSD symptoms using the Impact of Events Scale Revised (IES-R).
  • 115 participants underwent two [18F]flutemetamol PET scans over approximately 3.36 years to measure the change (Δ) in Aβ accumulation in predefined regions of interest (ROIs).
  • Linear regression models analyzed associations between demographic/clinical factors and PTSD scores, and specifically between ΔAβ in ROIs and PTSD total/sub-scores.

Main Results:

  • Higher total PTSD symptoms post-pandemic were reported by women, individuals with higher pre-pandemic anxiety (HADS), and those with a history of psychiatric illness.
  • Faster Aβ accumulation in the posterior cingulate gyrus was associated with higher total PTSD symptoms.
  • Accelerated Aβ accumulation across multiple ROIs (excluding a control area) correlated significantly with intrusion symptoms, but not with avoidance or hyperarousal sub-scores.

Conclusions:

  • A faster rate of early Aβ accumulation in brain regions critical for emotional processing may predispose individuals to stress-related symptoms, particularly intrusion.
  • Dynamic changes in Aβ pathology appear to play a role in emotional regulation and rumination, contributing to PTSD symptomatology.
  • Women and individuals with pre-existing mental health conditions exhibit heightened vulnerability to these effects.