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A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
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Clinical Manifestations.

Mayuri L Venkatesh1, Natalia Tarr1, Alexa Coussoule1

  • 1Department of Neurology, Massachusetts General Hospital/Brigham & Women's Hospital, Boston, MA, USA.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

This study optimized recruitment for a depression and dementia risk research project by using diverse strategies like clinician referrals and digital outreach. Future efforts will focus on improving diversity and addressing participation barriers for better understanding of late-life depression and Alzheimer's disease risk.

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Area of Science:

  • Gerontology and Cognitive Neurology
  • Psychiatry and Behavioral Science

Background:

  • Late-life depression and dementia are significant health concerns with complex interrelations.
  • Clinical research in this area faces substantial recruitment, diversity, and stigma-related challenges.
  • The Mood and Memory in Aging Study (MOMENT) aimed to address these by optimizing recruitment strategies.

Purpose of the Study:

  • To describe and evaluate recruitment and outreach strategies used in the MOMENT study.
  • To identify effective methods for recruiting older adults with late-life depression for dementia risk research.
  • To discuss challenges and future directions for improving research participation and diversity.

Main Methods:

  • A two-phase recruitment approach was used for non-demented older adults with depressive disorders.
  • Strategies included digital platforms, clinician referrals, community outreach, and partnerships.
  • Participant demographics and engagement metrics were analyzed to assess strategy effectiveness.

Main Results:

  • Enhanced recruitment efforts led to the study concluding one month ahead of schedule.
  • Clinician referrals, recruitment websites, and clinical databases were highly effective recruitment channels.
  • A 36% increase in weekly call volume was observed due to expanded outreach methods.
  • 56 participants were enrolled with a 22.2% screen-fail rate and ~85% retention.

Conclusions:

  • A multi-faceted recruitment strategy integrating referrals, ads, and registry partnerships proved efficient.
  • Challenges remain in enrolling diverse populations (e.g., Hispanic/Latino) and severely symptomatic individuals.
  • Future work will focus on translation, database expansion, and non-imaging options to enhance participation and address health disparities.