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Clinical Manifestations.

Monika Krejci1,2, Veronika Matuskova2, Toni T Saari3

  • 1Charles University, Faculty of Arts, Prague, Czech Republic.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|December 25, 2025
PubMed
Summary
This summary is machine-generated.

Neuropsychiatric symptoms (NPS) in early neurodegenerative disease are best assessed by combining patient self-reports with informant perspectives. Informant ratings correlate better with cognitive deficits, aiding early diagnosis.

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Area of Science:

  • Neuroscience
  • Gerontology
  • Psychiatry

Background:

  • Neuropsychiatric symptoms (NPS) in cognitive deficit are typically informant-assessed.
  • Patient self-perceptions offer valuable insights, especially in early neurodegenerative disease stages.
  • Previous studies show discrepancies between self- and informant-reported NPS.

Purpose of the Study:

  • To analyze differences in self- and informant-rated NPS using the Mild Behavioral Impairment Checklist (MBI-C).
  • To examine the association between NPS and the degree of cognitive deficit.
  • To compare self- and informant-rated NPS in individuals with subjective cognitive decline (SCD) and mild cognitive impairment (MCI).

Main Methods:

  • 127 non-demented older adults with cognitive complaints and their informants were recruited.
  • Participants were categorized into SCD (N=38), MCI (N=89), and control (N=26) groups.
  • Self- and informant-completed Czech MBI-C were analyzed for differences and correlations with cognition.

Main Results:

  • Both self- and informant-MBI-C scores were elevated in SCD and MCI groups compared to controls.
  • Informant ratings showed stronger associations with cognitive deficits (memory, executive functions) than self-ratings.
  • Informants reported more severe impulse control issues in the MCI group.

Conclusions:

  • Both self- and informant-rated NPS assessments are crucial for early neurodegenerative disease diagnosis.
  • Informant insights link NPS to cognitive deficits, while self-reports capture subjective experiences.
  • Combining both perspectives provides complementary data for diagnosis.